N-Methyl-D-Aspartic Acid Receptor Activation Downregulates Expression of d Subunit-Containing GABAA Receptors in Cultured Hippocampal Neurons
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چکیده
S Activation of UTP-Sensitive P2Y2 Receptor Induces the Expression of Cholinergic Genes in Cultured Cortical Neurons: A Signaling Cascade Triggered by Ca Mobilization and Extracellular Regulated Kinase Phosphorylation Roy C. Y. Choi, Glanice K. Y. Chu, Nina L. Siow, Amanda W. Y. Yung, Lisa Y. Yung, Pinky S. C. Lee, Christopher C. W. Lo, Joseph Simon, Tina T. X. Dong, Eric A. Barnard, and Karl W. K. Tsim 50
منابع مشابه
N-methyl-D-aspartic acid receptor activation downregulates expression of δ subunit-containing GABAA receptors in cultured hippocampal neurons.
Neurosteroids are endogenous allosteric modulators of GABAA receptors (GABARs), and they enhance GABAR-mediated inhibition. However, GABARs expressed on hippocampal dentate granule neurons of epileptic animals are modified such that their neurosteroid sensitivity is reduced and δ subunit expression is diminished. We explored the molecular mechanisms triggering this GABAR plasticity. In the cult...
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تاریخ انتشار 2013